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avrdude -p m644 -P /dev/ttyS1 -c ponyser -U flash:w:/home/user/Downloads/tobias_led1.hex -vvv

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root@debian:/usr/local/bin# avrdude -p m644 -P /dev/ttyS1 -c ponyser -U flash:w:/home/user/Downloads/tobias_led1.hex -vvv
avrdude: Version 5.11.1, compiled on Jan 17 2012 at 02:15:06
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2009 Joerg Wunsch
System wide configuration file is \"/usr/local/etc/avrdude.conf\"
User configuration file is \"/root/.avrduderc\"
User configuration file does not exist or is not a regular file, skipping
Using Port : /dev/ttyS1
Using Programmer : ponyser
/dev/ttyS1: tcgetattr: Input/output error
avrdude done. Thank you.